Fibre density and cross-section associate with hallmark pathology in early Alzheimer’s disease

Table 1 Demographical and clinical characteristics of included participants

Variable	HC	aMCI		P-value
		Baseline	Follow-up	HC vs. MCI_Base	MCI_Base vs. MCI_FU
N	23	24	14
Age, y	70 ± 9	73 ± 8	72 ± 8	0.3	N.A.
Sex (F/M), n	10/13	15/9	8/6	0.2	N.A.
Education, n				0.04	N.A.
Secondary education Higher education University	4 15 4	13 8 3	8 5 1
APOEε4 alleles (0/1/2), n	18/3/2	6/13/5	3/8/3	0.002	N.A.
Aβ (+/-/unknown), n	4/19/0	23/0/1	14/0/0	< 0.0001	N.A.
MMSE (0–30)	29.5 ± 0.8	25.2 ± 2.2	22.6 ± 2.6	< 0.0001	0.03
RAVLT Sum (0–75)	53.3 ± 9.0	29.0 ± 9.8	22.7 ± 5.5	< 0.0001	0.04
RCPM (0–24)	21.7 ± 2.0	17.6 ± 3.6	15.9 ± 4.5	< 0.0001	0.007
AVF	25.4 ± 7.4	14.9 ± 4.3	13.2 ± 3.1	< 0.0001	0.2
BNT (0–60)	56.2 ± 3.4	50.2 ± 7.6	48.2 ± 6.3	< 0.0001	0.001
TMT, s
TMT A TMT B	33.4 ± 12.1 83.1 ± 75.7	57.0 ± 23.6 179.3 ± 76.3	48.0 ± 15.7 163.9 ± 43.0	< 0.0001 < 0.0001	0.6 0.2
BDI (0–63)	3.6 ± 3.2	6.9 ± 5.7	6.2 ± 4.4	0.02	0.8
GDS (0–30)	2.7 ± 2.6	8.7 ± 5.7	8.0 ± 4.2	< 0.0001	0.1

Data are presented as mean ± SD. Significant findings are indicated in bolt. GDS and BDI were missing for one HC, baseline TMT A was missing for one aMCI and baseline TMT B was missing for two aMCI patients. Follow-up TMT A and B as well as BDI were missing in one aMCI patient. Aβ = amyloid-beta PET status; aMCI = amnestic mild cognitive impairment; Base = baseline; FU = follow-up; HC = healthy controls; MMSE = mini-mental state examination; N.A. = not applicable; RAVLT = Rey auditory verbal learning test

ISSN: 1758-9193