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Figure 2 | Alzheimer's Research & Therapy

Figure 2

From: Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems

Figure 2

Feedback between amyloid precursor protein and its proteolytic fragments. Inhibition is shown in red, enhancement in green; numbers are referred to in the text. Functionally different aggregation states for the Aβ-type peptides are collapsed into P3 and Aβ nodes for clarity. Aβ, amyloid beta protein; AICD, APP intracellular domain; APP, amyloid precursor protein; PKC, protein kinase C; sAPP, secreted amyloid precursor protein.

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Alzheimer's Research & Therapy

ISSN: 1758-9193