Figure 1

Case example pedigree. The proband was referred for genetic counseling with a clinical diagnosis of probable frontotemporal degeneration (FTD). The proband's father died in his 40s in a motor vehicle accident. Her mother died in her 40s of uterine cancer. Neither had any known neurodegenerative or psychiatric disease. The proband's daughter had a history of attempted suicide in her 20s, but no known longstanding psychiatric illness. No information is known about the proband's grandparents. At the time of the initial visit, the remainder of the family history was noncontributory. Subsequent to the proband's visit, her brother was diagnosed with amyotrophic lateral sclerosis (ALS).