Figure 8

Model validation with ApoE4 genotype in the Alzheimer's disease (AD) cortical network. Effect of additional synapse loss and cholinergic tone decrease as part of the ApoE4 genotype in the AD cortical network on relative changes in network working memory span. We assume a 3% loss for 1 ApoE4 allele and a 5% loss for two ApoE4 alleles. The datasuggest that the biggest negative effect of synapse loss is observed in the early stages.