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Table 1 Histone deacetylase 6 inhibition decreases total tau levels but not pathological tau

From: Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

Phosphorylation site

Saline

Tubastatin

P value

Source

Ser202/Thr205 (AT8)

0.8 ± 0.1

0.7 ± 0.1

0.46

Ana Spec, EGT group, Fremont, CA, USA

Ser396

0.5 ± 0.1

0. 6 ± 0.1

0.34

Ana Spec, EGT group, Fremont, CA, USA

Ser199/202

0.4 ± 0.1

0.5 ± 0.1

0.25

Ana Spec, EGT group, Fremont, CA, USA

Gallyas stain (NFTs)

1.3 ± 0.2

1.7 ± 0.4

0.21

Fischer scientific, Waltham, MA, USA

Total tau (H150)

2.2 ± 0.4

1.0 ± 0.2

0.03

Santa Cruz Biotechnology, Inc. Dallas, Texas, USA

  1. Mean ± SEM and P values are indicated for immunopositive p-tau stain in the rTg4510 saline-treated versus tubastatin-treated animals. Student’s t test, n = 6. NFT, neurofibrillary tangle.
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Alzheimer's Research & Therapy

ISSN: 1758-9193