Figure 4
From: Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
Acute reduction of brain Aβ by ELN318463 in PDAPP (a) and FVB mice (b). The mice were dosed orally with vehicle, or ELN318463 at 30 mg/kg or 100 mg/kg and sacrificed 3 h post treatment. Brain Aβ1-x in PDAPP (a), or Aβx-40 in FVB (b) was quantified by ELISA following extraction in guanidine buffer as described in methods. ** denotes P < 0.01, *** denotes P < 0.001 by Mann-Whitney in A, and two-tailed Students t-test in (b).