Amyloid imaging and memory change for prediction of cognitive impairment

Table 3 Amyloid imaging and prediction of conversion to Alzheimer's disease

Study	Year	Radiotracer	Sample^a	Number of subjects^a	Mean age (SD)	Method	Findings
Okello et al. [24]	2009	PiB	MCI	31	69.4 (7.9)	SUVR	82% PiB-positive MCI convert to AD compared to 7% of PiB-negative MCI 47% PiB-positive MCI who convert to AD within 1 year have higher PiB in anterior cingulate and frontal cortex (P < 0.05), APOE ε4 is associated with faster conversion rates in PiB-positive MCI (P < 0.05)
Wolk et al. [25]	2009	PiB	MCI	26 (23 with follow-up)	70.2 (8.8)	DVR	38% PiB-positive MCI but no PiB- convert to AD over 22 months
Morris et al. [45]	2009	PiB	CN	159	71.5 (8.6)	BP	Higher PiB retention predicts progression from CDR 0 to MCI (hazard ratio = 2.74) and AD (hazard ratio = 4.85) over mean 2.4 years
Koivunen et al. [44]	2008	PiB	aMCI	15	71.1 (7.2)	SUVR, DVR	Elevated PiB in six converters in posterior cingulate and frontal cortex as well as elevated neocortical score
Forsberg et al. [23]	2008	PiB	MCI	21	63.3 (7.8)	SUVR	Higher PiB retention in frontal, parietal, and temporal cortices (P < 0.01) in MCI converters than CN individuals Higher PiB retention in posterior cingulate gyrus in MCI converters than MCI nonconverters (P < 0.01) No difference in PiB retention between MCI converters and AD
Small et al. [20]	2006	[¹⁸F]FDDNP	AD, MCI, CN	4 MCI, 8 CN	NA for this subset	DVR	Three disease progressors had increases in [¹⁸F]FDDNP between 5.5% to 11.2% compared to ≤3% in nine non-progressors

^aIn some cases a study subsample. AD, Alzheimer's disease; aMCI, amnestic MCI; APOE, Apolipoprotein E; BP, binding potential; CN, cognitively normal; DVR, distribution volume ratio; MCI, mild cognitive impairment; NA, not available; PiB, [¹¹C]Pittsburgh Compound-B; SD, standard deviation; SUVR, standard uptake value ratio.

ISSN: 1758-9193