Figure 3
From: BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease
Neuronal substrates of BACE1. BACE1 substrates identified in primary cultured neurons are listed from those that are predominantly cleaved by BACE1 (BACE1 cleavage HIGH; top) to those that are processed by BACE1 at a low level (LOW; bottom). These substrates also are cleaved by other proteases in the ADAM family, but the ADAM cleavage preference is opposite to that of BACE1. (Adapted from Table I, Ref. [56]).