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Table 6 Logistic regression models showing the relationships between hippocampal pathologies and presence of clinical dementia

From: Re-examining tau-immunoreactive pathology in the population: granulovacuolar degeneration and neurofibrillary tangles

 

Model 1

Model 2

Model 3

 

OR

CI

p value

OR

CI

p value

OR

CI

p value

GVD-IR

 Mild

1.04

(0.25–4.38)

0.956

1.00

(0.23–4.35)

1.000

1.00

(0.22–4.52)

0.998

 Moderate

1.55

(0.38–6.31)

0.542

1.07

(0.24–4.76)

0.931

1.03

(0.22–4.80)

0.972

 Severe

7.48

(1.54–36.24)

0.012

3.90

(0.71–21.45)

0.118

3.81

(0.65–22.41)

0.139

NFT-IR

 Mild

1.21

(0.37–3.93)

0.753

1.26

(0.38–4.25)

0.705

1.39

(0.36–5.45)

0.635

 Moderate

2.27

(0.70–7.31)

0.170

1.66

(0.46–5.98)

0.435

2.61

(0.61–11.19)

0.198

 Severe

7.33

(2.01–26.80)

0.003

4.86

(1.17–20.28)

0.030

9.99

(1.97–50.54)

0.005

  1. Model 1 controlling for age and sex; model 2 additionally controlling for NFT and NP; model 3 additionally controlling for TDP-43 and amyloid deposits
  2. CI confidence interval, GVD granulovacuolar degeneration, IR immunoreactive, NFT neurofibrillary tangles, NP neuritic plaques, OR odds ratio, TDP-43 Tar-DNA binding protein 43
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Alzheimer's Research & Therapy

ISSN: 1758-9193