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Table 5 Executive function, working memory and planning test

From: Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software

Spatial Working Memory (SWM)

Drug

Name of task

Mean ± SEM

p1 value

95 % CI-D (Lower, Upper)

Cohen’s d for p1 Value

p2 Value

95 % CI-D (Lower, Upper)

Cohen’s d for p2 Value

Baseline

After 7 Days

OME

SWM BE

15.800 ± 3.123

29.500 ± 4.465

0.002**

−21.794, -5.606

2.553ǂ

0.111

−6.717, 26.917

0.595

SWM Strategy

32.500 ± 0.703

34.900 ± 0.924

0.012*

−4.401, -0.399

1.809ǂ

0.385

−4.038, 3.038

0.140

LAN

SWM BE

29.100 ± 5.664

34.900 ± 6.781

0.153

−17.906, 6.306

0.723

0.060

−4.444, 35.444

0.769

SWM Strategy

34.700 ± 0.895

37.700 ± 0.967

0.001***

−4.720, -1.280

2.631ǂ

0.097

−1.288, 5.888

0.635

RAB

SWM BE

22.500 ± 5.119

32.200 ± 7.360

0.016*

−18.429, -0.971

1.676ǂ

0.106

−8.031, 33.631

0.608

SWM Strategy

34.100 ± 1.215

36.500 ± 1.607

0.022*

−4.717, -0.083

1.562ǂ

0.306

−3.389, 5.589

0.243

PAN

SWM BE

21.600 ± 4.766

31.500 ± 6.114

0.095

−25.730, 5.930

0.943ǂ

0.098

−6.869, 31.069

0.632

SWM Strategy

33.400 ± 1.056

36.100 ± 1.027

0.010**

−4.861, -0.539

1.885ǂ

0.346

−2.961, 4.361

0.189

ESO

SWM BE

24.900 ± 4.451

28.800 ± 6.141

0.244

−16.126, 8.326

0.481

0.165

−9.606, 28.406

0.489

SWM Strategy

33.500 ± 0.719

35.200 ± 0.940

0.035*

−3.579, 0.179

1.365ǂ

0.453

−3.757, 3.357

0.055

CON

SWM BE

19.400 ± 4.492

19.400 ± 6.644

0.500

−11.406, 11.406

N/A

SWM Strategy

34.400 ± 1.046

35.400 ± 1.408

0.118

−2.784, 0.784

N/A

  1. Values are expressed as mean ± SEM (n=10), BE=Between Errors, 95 % CI-D=95 % Confidence Interval of the Difference (lower, upper), p1= p value found after Paired-Samples t-test within volunteers (five test groups) before and after consuming drugs and placebo (one control group) respectively with degree of freedom (df)=9; p2= p value found after Independent-Samples t-test between each five test groups with control group having degree of freedom (df)=18. *, ** and *** indicate statistically significant at alpha (<0.05), (<0.01) & (<0.001) respectively. ǂ indicates large effect size in Cohen’s d value
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Alzheimer's Research & Therapy

ISSN: 1758-9193