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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology

Fig. 4

The ratio of angiotensin II (Ang II) to angiotensin (1–7) (Ang (1-7)) (a proxy measure of ACE-2 activity) is increased, indicating reduced conversion of Ang II to Ang (1–7) in Alzheimer’s disease (AD). Bar charts showing a elevated Ang II levels in AD and b unchanged Ang (1–7) levels in AD compared with age-matched controls in mid-fontal cortex. c Bar chart showing the Ang II/Ang (1–7) ratio was significantly increased in AD (P < 0.001). The bars indicate the mean value and SEM. ***P < 0.001, ****P < 0.0001

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Alzheimer's Research & Therapy

ISSN: 1758-9193