SORL1 gene, plasma biomarkers, and the risk of Alzheimer’s disease for the Han Chinese population in Taiwan

Table 4 Associations between SORL1 rs1784933 and cognitive tests

Subjects	Cognitive tests	SORL1 rs1784933			p Value (ANOVA)
Subjects	Cognitive tests	AA	AG	GG	p Value (ANOVA)
Control subjects	MMSE score	28.0 ± 2.1	28.1 ± 1.9	27.6 ± 2.1	0.490
MCI	MMSE score	25.9 ± 2.9	26.0 ± 2.8	26.7 ± 2.4	0.468
	12-item word recall test	4.5 ± 3.0	4.5 ± 2.7	5.0 ± 2.6	0.877
	Forward digit span	10.0 ± 2.8	10.2 ± 2.1	9.1 ± 2.9	0.507
	Backward digit span	5.5 ± 2.5	6.1 ± 2.1	6.3 ± 3.2	0.271
	Verbal fluency test	10.1 ± 2.8	10.5 ± 3.4	9.5 ± 2.3	0.576
	Boston Naming Test	13.5 ± 1.2	13.8 ± 1.3	13.4 ± 1.4	0.290
	Trail Making Test A, seconds	99.7 ± 67.2	84.1 ± 38.9	74.4 ± 39.0	0.177
AD	MMSE score	18.1 ± 6.0	18.5 ± 5.7	18.5 ± 6.0	0.648
	12-item word recall test	1.3 ± 2.1	1.5 ± 2.2	1.5 ± 2.5	0.494
	Forward digit span	8.3 ± 3.1	8.6 ± 3.1	8.1 ± 2.2	0.224
	Backward digit span	3.8 ± 2.1	3.9 ± 2.2	3.5 ± 1.8	0.461
	Verbal fluency test	6.4 ± 3.3	6.5 ± 3.1	6.9 ± 2.8	0.537
	Boston Naming Test	11.2 ± 3.1	11.5 ± 2.9	11.9 ± 2.3	0.229
	Trail Making Test A, seconds	186.8 ± 160.5	175.6 ± 130.4	182.9 ± 115.2	0.630

Abbreviations: AD Alzheimer’s disease, MCI Mild cognitive impairment, SORL1 Sortilin-related receptor 1 gene, MMSE Mini Mental State Examination, ANOVA One-way analysis of variance

ISSN: 1758-9193