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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: LW-AFC, a new formula derived from Liuwei Dihuang decoction, ameliorates behavioral and pathological deterioration via modulating the neuroendocrine-immune system in PrP-hAβPPswe/PS1ΔE9 transgenic mice

Fig. 6

The effect of LW-AFC on the hormone secretion of the HPA and HPG axes in APP/PS1 mice. The hormones of the HPA axis including a corticotropin releasing hormone (CRH) in the hypothalamus, b adrenocorticotropic hormone (ACTH) in the pituitary, and c corticosterone (CORT) in the plasma. The HPG axis including d gonadotropin-releasing hormone (GnRH) in the hypothalamus, e luteinizing hormone (LH), and f follicle-stimulating hormone (FSH) in the pituitary. The values are mean ± SEM; n = 9–11. *P < 0.05, **P < 0.01, ***P < 0.001, versus the wild-type (WT) mouse group by unpaired Student's t test; # P < 0.05, ## P < 0.01, versus the APP/PS1 (Tgs) mouse group by one-way ANOVA analysis followed by Dunnett’s post hoc test

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Alzheimer's Research & Therapy

ISSN: 1758-9193