Table 3 Brain regions showing statistically significant gray matter volumetric decrease in pairwise comparisons between non-SCD, SCD+, and SCD– groups
Contrast | Label | MNI coordinates | Cluster | Peak | pFWE-corr | ||||
|---|---|---|---|---|---|---|---|---|---|
x | y | z | size | Z score | Peak | Cluster | |||
SCD– > SCD+ | Cluster 1 | Left temporal middle | −59 | −33 | −12 | 345 | 4.13 | 0.117 | 0.459 |
Left temporal inferior | |||||||||
Cluster 2 | Left temporal inferior | −33 | −15 | −44 | 801 | 4.05 | 0.151 | 0.164 | |
Left fusiform | |||||||||
Cluster 3 | Left temporal pole superior | −38 | −11 | −17 | 753 | 3.81 | 0.315 | 0.182 | |
Left temporal middle | |||||||||
Left temporal superior | |||||||||
Left temporal pole middle | |||||||||
Cluster 4 | Right cerebellum | 30 | −74 | −20 | 734 | 3.73 | 0.393 | 0.190 | |
Right Fusiform | |||||||||
Cluster 5 | Left postcentral | −53 | −20 | 30 | 208 | 3.72 | 0.401 | 0.625 | |
Left supramarginal | |||||||||
Cluster 7 | Right cerebellum | 12 | −66 | −47 | 556 | 3.72 | 0.403 | 0.283 | |
Vermis | |||||||||
Cluster 8 | Vermis | −2 | −59 | −18 | 1540 | 3.68 | 0.437 | 0.037 | |
Left cerebellum | |||||||||
Left fusiform | |||||||||
Right cerebellum | |||||||||
Cluster 9 | Left cerebellum | −14 | −68 | −45 | 559 | 3.63 | 0.494 | 0.281 | |
Cluster 10 | Left occipital superior | −17 | −77 | 29 | 340 | 3.59 | 0.536 | 0.464 | |
Left precuneus | |||||||||
Left cuneus | |||||||||
Cluster 11 | Right temporal inferior | 47 | −9 | −38 | 420 | 3.59 | 0.541 | 0.386 | |
Right temporal pole | |||||||||
Right fusiform | |||||||||
Cluster 12 | Left temporal superior | −54 | −45 | 15 | 428 | 3.54 | 0.593 | 0.379 | |
Left temporal middle | |||||||||
SCD– > non-SCD | Cluster 1 | Left temporal pole superior | −45 | 6 | −17 | 4502 | 4.66 | 0.015 | 0.000 |
Left fusiform | |||||||||
Left temporal pole middle | |||||||||
Left temporal superior | |||||||||
Left hippocampus | |||||||||
Left parahippocampal | |||||||||
Left insula | |||||||||
Left amygdala | |||||||||
Cluster 2 | Left cuneus | −17 | −63 | 33 | 2216 | 4.56 | 0.022 | 0.011 | |
Left occipital superior | |||||||||
Left precuneus | |||||||||
Right cuneus | |||||||||
Left calcarine | |||||||||
Cluster 3 | Right fusiform | 30 | −77 | −17 | 956 | 4.31 | 0.061 | 0.118 | |
Right cerebellum | |||||||||
Right lingual | |||||||||
Right occipital inferior | |||||||||
Cluster 4 | Left lingual | 2 | −57 | −18 | 3020 | 4.28 | 0.068 | 0.003 | |
Vermis | |||||||||
Left cerebellum | |||||||||
Left fusiform | |||||||||
Cluster 5 | Right temporal pole middle | 39 | 9 | −33 | 1723 | 4.15 | 0.109 | 0.026 | |
Right temporal inferior | |||||||||
Right temporal pole superior | |||||||||
Cluster 6 | Right frontal inferior | 50 | 2 | 20 | 1157 | 4.11 | 0.126 | 0.078 | |
Right rolandic | |||||||||
Right precentral | |||||||||
Cluster 7 | Left temporal middle | −59 | −33 | −12 | 317 | 3.99 | 0.183 | 0.489 | |
Left temporal inferior | |||||||||
Cluster 8 | Left occipital middle | −32 | −75 | 15 | 123 | 3.93 | 0.220 | 0.749 | |
Cluster 9 | Right supramarginal | 45 | −30 | 33 | 189 | 3.72 | 0.404 | 0.651 | |
Right postcentral | |||||||||
Cluster 10 | Left temporal superior | −59 | −35 | 12 | 250 | 3.58 | 0.551 | 0.569 | |
Left temporal middle | |||||||||
Cluster 11 | Left postcentral | −53 | −17 | 32 | 396 | 3.58 | 0.554 | 0.408 | |
Left parietal inferior | |||||||||
Left supramarginal | |||||||||
Cluster 12 | Right cerebellum | −3 | −68 | −45 | 489 | 3.56 | 0.601 | 0.330 | |
Left cerebellum | |||||||||
Cluster 13 | Left rolandic | −60 | −3 | 12 | 229 | 3.53 | 0.624 | 0.596 | |
Left postcentral | |||||||||
Cluster 14 | Right occipital superior | 26 | −71 | 33 | 109 | 3.40 | 0.617 | 0.771 | |