Fig. 2
From: The dynamics of biomarkers across the clinical spectrum of Alzheimer’s disease

Probabilities and times to a more severe clinical state. Probabilities of transitioning to a more severe state within 1 year (top), and the expected time to reach a more severe state (bottom), as a function of age in the groups of carriers and non-carriers of APOE ε4. The shaded area represents the values within one standard deviation from the mean transition probabilities