Fig. 4
From: The dynamics of biomarkers across the clinical spectrum of Alzheimer’s disease
Normalised trajectories and rates of change. Top row: normalised (min-max) trajectories of cognitive, CSF and neuroimaging markers, where ‘normal’ is the value in healthy CN individuals (as tADem → − ∞) and ‘abnormal’ is the value in severe ADem individuals (as tADem → ∞). Bottom row: rate of change of the (normalised) values of cognitive, CSF and neuroimaging markers. The vertical dashed and thick dotted lines represent the average expected time from ADem onset of individuals that are CN (27.75 years) and MCI (9.63 years) at baseline, respectively