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Table 3 Statistically significant DEmiRNAs identified by the meta-analysis

From: Prediction of differentially expressed microRNAs in blood as potential biomarkers for Alzheimer’s disease by meta-analysis and adaptive boosting ensemble learning

MiRNAs

Comparison ID

Number of upregulated case in AD

Number of downregulated case in AD

Number of control case

Weight

P value

FDR

LogOR

95% CI

τ^2

I^2

miR-107

27501295_WB

 

172

109

25.08%

3.74E−25

1.61E−23

− 10.40

[− 12.36 , − 8.43]

0.00

0.00%

25742200_Pla

 

97

81

25.03%

      

23895045_WB

 

94

21

24.82%

      

31420923_Pla

 

120

120

25.07%

      

miR-106b-3p

29036818_Ser_Mild

31

 

86

24.98%

1.05E−20

1.53E−19

9.38

[7.41 , 11.35]

0.00

0.00%

29036818_Ser_Mod

52

 

86

25.06%

      

29036818_Ser_Sev

38

 

86

25.01%

      

28626163_Ser

45

 

40

24.96%

      

miR-22-3p

29036818_Ser_Mild

 

31

86

24.98%

1.07E−20

1.53E−19

− 9.38

[− 11.34 , − 7.41]

0.00

0.00%

29036818_Ser_Mod

 

52

86

25.06%

      

29036818_Ser_Sev

 

38

86

25.01%

      

29746584_Ser

 

47

38

24.95%

      

miR-126-5p

29036818_Ser_Mild

 

31

86

33.28%

2.06E−16

1.48E−15

− 9.53

[− 11.81 , − 7.26]

0.00

0.00%

29036818_Ser_Mod

 

52

86

33.39%

      

29036818_Ser_Sev

 

38

86

33.33%

      

miR-148b-5p

29036818_Ser_Mild

 

31

86

33.28%

2.06E−16

1.48E−15

− 9.53

[− 11.81 , − 7.26]

0.00

0.00%

29036818_Ser_Mod

 

52

86

33.39%

      

29036818_Ser_Sev

 

38

86

33.33%

      

miR-181c-3p

29036818_Ser_Mild

 

31

86

33.28%

2.06E−16

1.48E−15

− 9.53

[− 11.81 , − 7.26]

0.00

0.00%

29036818_Ser_Mod

 

52

86

33.39%

      

29036818_Ser_Sev

 

38

86

33.33%

      

miR-128-3p

27239545_PBMC

30

 

30

25.02%

4.64E−16

2.85E−15

8.19

[6.21 , 10.17]

0.00

0.00%

24064186_PBMC_Mon

34

 

37

25.08%

      

24064186_PBMC_Lym

34

 

37

25.08%

      

30328325_Pla

20

 

20

24.82%

      

miR-93-5p

26078483_Ser

 

79

75

50.13%

2.3E−11

1.24E−10

− 9.50

[− 12.28 , − 6.71]

0.00

0.00%

28626163_Ser

 

45

40

49.87%

      

miR-29c-3p

25955795_WB

 

30

30

49.88%

1.81E−09

8.65E−09

− 8.56

[− 11.36 , − 5.77]

0.00

0.00%

28626163_Ser

 

45

40

50.12%

      

miR-132-3p

29746584_Ser

 

47

38

50.28%

6.67E−09

2.87E−08

− 8.27

[− 11.07 , − 5.48]

0.00

0.00%

31849573_Pla

 

16

31

49.72%

      

miR-222-3p

28849039_Ser_Mil

 

30

30

50.00%

8.09E−09

3.16E−08

− 8.22

[− 11.02 , − 5.43]

0.00

0.00%

28849039_Ser_Mod

 

30

30

50.00%

      

miR-34c-5p

24550773_Pla

25

 

27

50.00%

2.67E−08

9.58E−08

7.94

[5.14 , 10.74]

0.00

0.00%

24550773_PBMC

25

 

27

50.00%

      

let-7d-5p

23922807_Pla_C2

 

20

17

49.74%

8.9E−06

2.73E−05

− 9.39

[− 13.54 , − 5.25]

4.89

54.62%

24577456_Ser

 

158

155

50.26%

      

miR-191-5p

23922807_Pla_C2

 

20

17

49.74%

8.9E−06

2.73E−05

− 9.39

[− 13.54 , − 5.25]

4.89

54.62%

24577456_Ser

 

158

155

50.26%

      

miR-200a-3p

28179587_Pla_AD2

13

 

9

50.26%

3.37E−05

8.05E−05

6.01

[3.17 , 8.85]

0.00

0.00%

28179587_Pla_MCI-AD2

8

 

9

49.74%

      

miR-483-5p

28179587_Pla_AD2

13

 

9

50.26%

3.37E−05

8.05E−05

6.01

[3.17 , 8.85]

0.00

0.00%

28179587_Pla_MCI-AD2

8

 

9

49.74%

      

miR-486-5p

28179587_Pla_AD2

13

 

9

50.26%

3.37E−05

8.05E−05

6.01

[3.17 , 8.85]

0.00

0.00%

28179587_Pla_MCI-AD2

8

 

9

49.74%

      

miR-502-3p

28179587_Pla_AD2

13

 

9

50.26%

3.37E−05

8.05E−05

6.01

[3.17 , 8.85]

0.00

0.00%

28179587_Pla_MCI-AD2

8

 

9

49.74%

      
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Alzheimer's Research & Therapy

ISSN: 1758-9193