Fig. 1

Manhattan plot for the EWAS meta-analysis using AD case–control status across three EC datasets. The red line indicates the experiment-wide significance threshold of 1.64E-07, whereas the purple line indicates the suggestive significance threshold of 1.00E-05. CpGs with experiment-wide significant association are marked in red and annotated with the gene name according to the Illumina manifest (v1.0 B5). CpGs around LIPE, TENT5A, and PALD1 are novel