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Table 5 Results of the group-wise LMM analysis performed to evaluate change in parieto-occipital EEG measures over time (in months) in Aβ + MCI or AD dementia patients. Regression coefficients (β) and 95% confidence intervals (CI) of the Time effects are reported. Estimates for the Group*Time interaction effects, as well as estimates adjusted for age, sex and medication use are presented in Additional file 2 (Table S4)

From: Longitudinal resting-state EEG in amyloid-positive patients along the Alzheimer’s disease continuum: considerations for clinical trials

Region

Measure

Frequency band

Disease stage

β

95% CI

p-value

Parieto-occipital

Relative power

Theta

MCIb

1.6E-03

8.3E-04

2.3E-03

 < .001***

 

AD dementiab

8.7E-04

-2.0E-04

1.9E-03

0.12

Alpha1

MCIa

3.8E-04

-1.1E-03

1.9E-03

0.62

 

AD dementiaa

-1.2E-03

-3.0E-03

5.2E-04

0.17

Alpha2

MCIa

-1.3E-04

-1.5E-03

1.2E-03

0.86

 

AD dementiaa

-4.5E-04

-2.0E-03

1.1E-03

0.58

Beta

MCIa

-1.0E-03

-1.8E-03

-2.7E-04

 < .01**

 

AD dementiaa

-5.0E-04

-1.4E-03

3.9E-04

0.27

Peak frequency

-

MCIa

-1.0E-02

-2.1E-02

1.2E-03

0.08

 

AD dementiaa

-2.3E-02

-3.6E-02

-9.6E-03

 < .001***

AEC-c

Alpha

MCIa

-1.5E-04

-6.1E-04

3.1E-04

0.53

 

AD dementiaa

2.1E-05

-5.1E-04

5.5E-04

0.94

Beta

MCIa

-7.1E-05

-2.4E-04

9.9E-05

0.41

 

AD dementiaa

-1.2E-04

-3.2E-04

7.5E-05

0.22

PLI

Theta

MCIa

1.9E-04

-3.4E-04

7.2E-04

0.48

 

AD dementiaa

2.1E-04

-4.1E-04

8.3E-04

0.50

PE

Theta

MCIa

-2.4E-05

-2.5E-04

2.0E-04

0.84

 

AD dementiaa

-2.0E-04

-4.6E-04

6.4E-05

0.14

wSMI

Theta

MCIa

-1.8E-05

-1.9E-04

1.5E-04

0.83

 

AD dementiaa

1.4E-04

-5.2E-05

3.4E-04

0.15

JPEinv

Theta

MCIa

7.6E-07

-1.4E-04

1.4E-04

0.99

 

AD dementiaa

-1.3E-04

-2.9E-04

3.6E-05

0.13

  1. AEC-c Corrected amplitude envelope correlation, PLI Phase lag index, PE Permutation entropy, wSMI Weighted symbolic mutual information, JPEinv Inverted joint permutation entropy
  2. *p<.05, **p<.01, ***p<.001
  3. aRandom intercept on subject level
  4. bRandom intercept and random slope on subject level