Fig. 3

Association analysis results of module eigengenes with diagnosis and clinical and pathological traits. A The numbers represent the logistic and linear regression coefficients of association between module eigengenes and traits. Stars indicate significant associations with FDR-corrected p value < 0.05. Red colors represent positive correlations, while blue colors denote negative correlations. The darker the color, the stronger the association. B Violin and box plots represent the M3 module eigengene values in the diagnosis, amyloidopathy, and tauopathy groups from the ROS/MAP cohort. C The x-axis represents years before the last clinical evaluation, while the y-axis indicates global cognitive Z scores. The two lines represent the different slopes of global cognitive changes of subjects with 1st quartile (green color) versus 4th quartile (red color) stratified by ME values of AD-associated M3 module. AD Alzheimer’s dementia, CERAD Consortium to Establish a Registry for Alzheimer’s Disease, FDR false discovery rate, MAP Memory and Aging Project, ME module eigengene, NCI no cognitive impairment, ROS Religious Orders Study. Note: significance stars indicating the p values of the correlations adjustment for multiple comparisons. *P-value < 0.05. **P-value < 0.01