Fig. 5
From: miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer’s disease
Construction of consensus module eigengene networks. A, B Heatmaps showing the adjacencies of eigengene for each of the eigengene networks (A, ROS/MAP cohort; B, GSE157239 cohort). Each row and column corresponds to an eigengene labeled by the consensus module or diagnosis. Red colors represent positive correlations, while blue colors denote negative correlations. The darker the color, the stronger the association. C Adjacency heatmap displaying the pairwise preservation between the two consensus eigengene networks. Each row and column corresponds to an eigengene labeled by the consensus module or diagnosis. Red colors represent adjacency. The darker the color, the higher the adjacency. D Bar plot showing the preservation of correlation of consensus module eigengene between the two networks. Each colored bar corresponds to the eigengene of the associated consensus module. The height of the bar (y-axis) represents the eigengene preservation measure. The D value indicates the mean preservation of eigengene networks across the datasets. The high density value of D (= 0.88) denotes high overall preservation between the two networks. AD Alzheimer’s dementia, CM consensus module, M module, MAP Memory and Aging Project, ROS Religious Orders Study