miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer’s disease

Table 2 Results of differential expression analysis of AD-associated target genes of five AD-associated hub miRNAs between NCI and AD. Here we showed only significantly differentially expressed target genes in AD

miR-129-5p		miR-433		miR-1260		miR-200a		miR-221
Target genes	P value ^a	Target genes	P value ^a	Target genes	P value ^a	Target genes	P value ^a	Target genes	P value ^a
PIEZO2	0.001	BRWD1	0.036	SAMD4A	0.005	SLC6A9	< 0.001	DYNC1LI2	0.002
NRN1	0.015	NSMCE1	0.036	NRN1	0.022	C17orf58	0.005	MLIP	0.012
ZNF704	0.015	ST8SIA4	0.036	MID1IP1	0.022	SLFN5	0.025	BRWD1	0.012
COX15	0.030			LGMN	0.023	TNS3	0.025	NRIP2	0.012
CHD7	0.030			TBC1D24	0.023	SLC38A2	0.025	ZFR2	0.012
PCDH8	0.030			LRRC73	0.033	RUFY2	0.027	ZNF652	0.012
TOMM40	0.030			GOLGA8B	0.033	CHP1	0.035	EML6	0.012
SMARCC1	0.030			CCDC113	0.036	BRWD1	0.035	LPAR1	0.012
RAB3B	0.030			RHNO1	0.041	LRRC8B	0.035	KIF1C	0.012
TMEM67	0.030			LIMD2	0.041	STAT4	0.035	RAB3B	0.014
USP13	0.030			BCKDK	0.044	DAP3	0.035	PTP4A2	0.016
SEPHS1	0.030			TRAPPC6A	0.044	TCERG1	0.035	NAP1L5	0.016
NRXN3	0.035					TATDN3	0.035	AKAP5	0.017
PAK3	0.038					MTF2	0.035	NXPH1	0.023
IGSF3	0.039					SLC20A1	0.038	PLXNC1	0.023
TSPYL4	0.039					ZNF652	0.041	PCDHGC5	0.023
SKP1	0.039					SLC4A1AP	0.043	NDFIP1	0.023
ZDHHC23	0.042					BTF3L4	0.043	ATP9B	0.023
GRM7	0.042					FBXL2	0.043	C11orf87	0.023
C2orf88	0.042					PCDH8	0.043	CAMK4	0.024
CKAP4	0.046					GULP1	0.043	COPS7A	0.026
CBX4	0.049					MFN1	0.043	PGAP1	0.030
						GRHL1	0.043	PPP1R14C	0.030
						FOXJ1	0.043	LRFN2	0.036
						KIF1C	0.043	STMN1	0.048
						CHD7	0.043
						NRIP3	0.047
						RHEB	0.049
						MBTPS2	0.049
						SEPT8	0.049

AD Alzheimer’s dementia, FDR false discovery rate, miRNAs microRNAs, NCI no cognitive impairment
^a Adjusted p value using FDR

ISSN: 1758-9193