miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer’s disease

Table 3 KEGG pathway analysis of target genes of five AD-associated hub miRNAs (miR-129-5p, miR-1260, miR-200a, miR-433, and miR-221)

KEGG pathway	Number of target genes belonging to the pathway	Fold enrichment	P value ^a
Axon guidance	31	2.931	< 0.001
ErbB signaling pathway	20	4.048	< 0.001
MAPK signaling pathway	35	1.994	0.012
GABAergic synapse	16	3.093	0.014
Autophagy - animal	21	2.562	0.015
AMPK signaling pathway	19	2.702	0.017
mTOR signaling pathway	22	2.426	0.020
Glutamatergic synapse	18	2.693	0.032

AD Alzheimer’s dementia, AMPK 5′ adenosine monophosphate-activated protein kinase, ErbB erythroblastic leukemia viral oncogene homolog, GABAergic gamma-aminobutyric acid-ergic, KEGG Kyoto Encyclopedia of Genes and Genomes, MAPK mitogen-activated protein kinase, miRNAs microRNAs, mTOR mammalian target of rapamycin
^aAdjusted p value from Bonferroni correction

ISSN: 1758-9193