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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Deciphering the effect of phytosterols on Alzheimer’s disease and Parkinson’s disease: the mediating role of lipid profiles

Fig. 1

Flowchart for this study. The red cross sign means genetic variables not associated with confounding factors and outcomes. Assumption 1 indicates that SNPs are strongly associated with circulating phytosterols levels; Assumption 2 indicates that SNPs are not associated with confounding factors; Assumption 3 indicates that SNPs affect the risk of outcomes via circulating phytosterols levels directly. AD, Alzheimer’s disease; PD, Parkinson’s disease; PD AAO, Parkinson’s disease age at onset; SNP, single nucleotide polymorphism; LD, linkage disequilibrium; IPDGC, International Parkinson Disease Genomics Consortium; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; UVMR, univariable Mendelian randomization; MVMR, multivariable Mendelian randomization; UKB, UK Biobank; IGAP, International Genomics of Alzheimer’s Project; N, number

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Alzheimer's Research & Therapy

ISSN: 1758-9193