Table 1 Demographics of participant

a) Participants’ demographics by brain amyloid PET result

J-TRC

BioFINDER

Aβ-PET negative

Aβ-PET positive

p-value

Aβ-PET negative

Aβ-PET positive

p-value

N, (%)

393(83)

81(17)

108(61)

69(39)

PET tracer; FBP/FMM, (%)

180(46)/213(54)

22(27)/59(73)

0/108

0/69

Age (mean ± SD, years)

71.2 ± 6.5

73.5 ± 6.3

0.0015

71.5 ± 5.9

73.5 ± 4.9

0.023

Male/Female, (%)

224(57)/169(43)

44(54)/37(46)

N.S

49(45)/59(55)

34(49)/35(51)

N.S

Education (mean ± SD, years)

14.4 ± 2.4

14.1 ± 2.8

N.S

11.9 ± 3.5

11.0 ± 3.0

N.S

APOE ε4 +/- , (%)

61(16)/332(84)

35(43)/46(57)

 < 0.001

22(21)/84(79)

50(72)/19(28)

< 0.001

CDR 0/CDR 0.5 (J-TRC), (%)

CU/MCI (BioFINDER), (%)

289(74)/104(26)

42(52)/39(48)

 < 0.001

83(77)/25(23)

31(45)/38(55)

< 0.001

MMSE (mean ± SD)

28.2 ± 1.9

27.4 ± 2.6

0.029

28.4 ± 1.6

27.6 ± 1.7

0.001

WMS Logical Memory IIa; Delayed Recall (mean ± SD)

8.6 ± 4.2

6.2 ± 4.9

 < 0.001

N.A

N.A

WAIS-R; Digit Symbol Substitution Test (mean ± SD)

49.6 ± 12.2

43.9 ± 11.2

 < 0.001

N.A

N.A

FCSRT (mean ± SD)

46.7 ± 3.2

43.7 ± 6.9

 < 0.001

N.A

N.A

CFI (mean ± SD)

Self

3.4 ± 2.4

4.7 ± 3.0

 < 0.001

N.A

N.A

Study partner

1.6 ± 1.7

2.7 ± 2.6

 < 0.001

N.A

N.A

Plasma Aβ42/40 (mean ± SD)

0.043 ± 0.009

0.034 ± 0.006

 < 0.001

0.053 ± 0.006

0.046 ± 0.004

 < 0.001

Plasma p-tau217 (mean ± SD, pg/ml)

0.16 ± 0.08

0.33 ± 0.17

 < 0.001

0.17 ± 0.06

0.32 ± 0.14

 < 0.001

PET Centiloid Scale (mean ± SD)

-0.19 ± 11.46

52.02 ± 31.14

 < 0.001

N.A

N.A

b) Participants’ demographics by cognitive assessment

J-TRC

BioFINDER

CDR 0

CDR 0.5

p-value

CU

MCI

p-value

N, (%)

331(70)

143(30)

114(64)

63(36)

Age (mean ± SD, years)

70.7 ± 6.4

73.8 ± 6.3

 < 0.001

72.9 ± 5.4

71.1 ± 5.8

0.036

Male/Female, (%)

191(58)/140(42)

77(54)/66(46)

N.S

43(38)/71(62)

40(63)/23(37)

0.001

Education (mean ± SD, years)

14.5 ± 2.5

13.8 ± 2.5

0.0075

12.1 ± 3.2

10.6 ± 3.4

0.004

APOE ε4 +/- , (%)

59(18)/272(82)

37(26)/106(74)

N.S

42(38)/70(64)

30(48)/33(52)

N.S

Aβ-PET -/+ , (%)

289(87)/42(13)

104(73)/39(27)

 < 0.001

83(73)/31(27)

25(40)/38(60)

 < 0.001

MMSE (mean ± SD)

28.5 ± 1.7

27 ± 2.4

 < 0.001

28.7 ± 1.3

27.0 ± 1.7

 < 0.001

WMS Logical Memory IIa; Delayed Recall (mean ± SD)

9.2 ± 4.1

5.8 ± 4.3

 < 0.001

N.A

N.A

WAIS-R; Digit Symbol Substitution Test (mean ± SD)

50.8 ± 11.8

43.7 ± 11.8

 < 0.001

N.A

N.A

FCSRT (mean ± SD)

47.1 ± 1.5

44.1 ± 7.0

 < 0.001

N.A

N.A

CFI (mean ± SD)

Self

3.1 ± 2.2

4.8 ± 2.9

 < 0.001

N.A

N.A

Study partner

1.3 ± 1.4

2.8 ± 2.4

 < 0.001

N.A

N.A

Plasma Aβ42/40 (mean ± SD)

0.043 ± 0.009

0.041 ± 0.012

0.0023

0.051 ± 0.006

0.048 ± 0.005

 < 0.001

Plasma p-tau217 (mean ± SD, pg/ml)

0.17 ± 0.08

0.24 ± 0.18

 < 0.001

0.20 ± 0.09

0.28 ± 0.15

 < 0.001