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Table 2 Results of the DeLong test comparing AUC of combinations of biomarkers for predicting amyloid PET positivity in the J-TRC cohort

From: Combining plasma Aβ and p-tau217 improves detection of brain amyloid in non-demented elderly

  

p-tau217

p-tau217/Aβ42

p-tau217 + Aβ42/40

Aβ42/40 + CI

p-tau217 + CI

p-tau217/Aβ42 + CI

p-tau217 + Aβ42/40 + CI

ALL

Aβ42/40

N.S

N.S

 < 0.001

N.S

N.S

0.0092

 < 0.001

p-tau217

 

N.S

N.S

N.S

N.S

N.S

N.S

p-tau217/Aβ42

  

N.S

N.S

N.S

N.S

N.S

p-tau217 + Aβ42/40

   

0.0010

N.S

N.S

N.S

Aβ42/40 + CI

    

N.S

0.014

 < 0.001

p-tau217 + CI

     

N.S

N.S

p-tau217/Aβ42 + CI

      

N.S

CDR 0

Aβ42/40

N.S

N.S

0.013

N.S

N.S

N.S

0.016

p-tau217

 

N.S

0.012

N.S

N.S

0.034

0.012

p-tau217/Aβ42

  

0.049

N.S

N.S

N.S

N.S

p-tau217 + Aβ42/40

   

0.032

N.S

N.S

N.S

Aβ42/40 + CI

    

N.S

N.S

0.093

p-tau217 + CI

     

N.S

0.035

p-tau217/Aβ42 + CI

      

N.S

CDR 0.5

Aβ42/40

N.S

N.S

N.S

N.S

N.S

N.S

N.S

p-tau217

 

N.S

N.S

N.S

N.S

N.S

N.S

p-tau217/Aβ42

  

N.S

N.S

N.S

N.S

N.S

p-tau217 + Aβ42/40

   

N.S

N.S

N.S

N.S

Aβ42/40 + CI

    

N.S

N.S

N.S

p-tau217 + CI

     

N.S

N.S

p-tau217/Aβ42 + CI

      

N.S

  1. CI Clinical information including age, sex, and APOE, CDR Clinical dementia rating (global score)
  2. p-values were adjusted by Benjamini–Hochberg method. N.S.: not significant