Table 3 AUC, sensitivity, specificity, PPV, NPV, AIC by individual modeling in the J-TRC cohort

AUC (95% CI)

sensitivity

specificity

PPV

NPV

AIC

a)

Total (N  =  474)

 Aβ42/40

0.856 (0.808–0.904)

0.876

0.712

0.385

0.965

322.07

 Aβ42/40 + Age + Sex + APOE

0.870 (0.827–0.913)

0.851

0.743

0.405

0.960

311.73

 p-tau217

0.913 (0.879–0.948)

0.839

0.865

0.561

0.963

299.84

 p-tau217 + Age + Sex + APOE

0.926 (0.893–0.959)

0.901

0.862

0.574

0.976

276.36

 p-tau217/Aβ42

0.912 (0.874–0.950)

0.814

0.923

0.687

0.960

247.6

 p-tau217/Aβ42 + Age + Sex + APOE

0.936 (0.906–0.965)

0.827

0.921

0.683

0.962

218.26

 p-tau217 + Aβ42/40

0.920 (0.884–0.957)

0.827

0.900

0.632

0.961

250.51

 p-tau217 + Aβ42/40 + Age + Sex + APOE

0.932 (0.901–0.963)

0.975

0.737

0.434

0.993

237.99

b)

CDR 0 group (N = 331)

 Aβ42/40

0.876 (0.831–0.922)

0.904

0.733

0.330

0.981

185.67

 Aβ42/40 + Age + Sex + APOE

0.884 (0.842–0.927)

0.976

0.657

0.292

0.994

183.43

 p-tau217

0.889 (0.832–0.945)

0.761

0.896

0.516

0.962

153.01

 p-tau217 + Age + Sex + APOE

0.911 (0.863–0.96)

0.857

0.837

0.433

0.975

147.68

 p-tau217/Aβ42

0.902 (0.847–0.956)

0.761

0.941

0.653

0.964

146.24

 p-tau217/Aβ42 + Age + Sex + APOE

0.928 (0.888–0.968)

0.809

0.896

0.531

0.970

140.11

 p-tau217 + Aβ42/40

0.938 (0.902–0.975)

0.833

0.944

0.686

0.975

129.83

 p-tau217 + Aβ42/40 + Age + Sex + APOE

0.948 (0.919–0.977)

0.952

0.813

0.425

0.991

130.35

c)

CDR 0.5 group (N = 143)

 Aβ42/40

0.830 (0.74–0.920)

0.743

0.875

0.690

0.900

133.86

 Aβ42/40 + Age + Sex + APOE

0.850 (0.768–0.931)

0.820

0.826

0.64

0.924

132.74

 p-tau217

0.925 (0.881–0.969)

0.897

0.826

0.660

0.955

129.55

 p-tau217 + Age + Sex + APOE

0.929 (0.887–0.972)

0.846

0.903

0.767

0.94

117.24

 p-tau217/Aβ42

0.916 (0.862–0.970)

0.897

0.865

0.714

0.957

100.44

 p-tau217/Aβ42 + Age + Sex + APOE

0.955 (0.922–0.989)

0.923

0.913

0.8

0.999

80.93

 p-tau217 + Aβ42/40

0.885 (0.810–0.960)

0.769

0.961

0.882

0.917

109.99

 p-tau217 + Aβ42/40 + Age + Sex + APOE

0.914 (0.856–0.971)

0.846

0.884

0.733

0.938

103.13