Table 2 Incidence and risk of young-onset dementia diagnosed before the age of 65 years based on the status of depression and menopause
From: Association between depression and young-onset dementia in middle-aged women
Depression | No. | Event (n) | Person-years | IRa | HR (95% CI) | ||||
|---|---|---|---|---|---|---|---|---|---|
Model 1b | Model 2c | Model 3d | Model 4e | ||||||
Any dementia | |||||||||
Premenopausal women | No | 915,595 | 1,972 | 8,505,861 | 0.23 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
Yes | 31,336 | 223 | 290,499 | 0.77 | 3.30 (2.88, 3.79) | 2.88 (2.51, 3.31) | 2.71 (2.54, 3.12) | 2.67 (2.32, 3.07) | |
Postmenopausal women | No | 634,535 | 5,998 | 5,056,422 | 1.19 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
Yes | 39,885 | 1,004 | 309,999 | 3.24 | 2.74 (2.57, 2.93) | 2.63 (2.46, 2.81) | 2.54 (2.37, 2.71) | 2.50 (2.34, 2.67) | |
Alzheimer’s dementia | |||||||||
Premenopausal women | No | 915,595 | 1,254 | 8,505,861 | 0.15 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
Yes | 31,336 | 163 | 290,499 | 0.56 | 3.78 (3.22, 4.46) | 3.26 (2.77, 3.84) | 3.10 (2.63, 3.65) | 3.05 (2.59, 3.59) | |
Postmenopausal women | No | 634,535 | 4,260 | 5,056,422 | 0.84 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
Yes | 39,885 | 750 | 309,999 | 2.42 | 2.89 (2.67, 3.12) | 2.77 (2.56, 2.99) | 2.68 (2.48, 2.90) | 2.63 (2.43, 2.85) | |
Vascular dementia | |||||||||
Premenopausal women | No | 915,595 | 457 | 8,505,861 | 0.05 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
Yes | 31,336 | 39 | 290,499 | 0.13 | 2.51 (1.81, 3.49) | 2.28 (1.65, 3.17) | 2.07 (1.49, 2.87) | 2.03 (1.46, 2.82) | |
Postmenopausal women | No | 634,535 | 985 | 5,056,422 | 0.19 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
Yes | 39,885 | 122 | 309,999 | 0.39 | 2.03 (1.68, 2.45) | 1.97 (1.63, 2.37) | 1.85 (1.53, 2.23) | 1.85 (1.53, 2.23) | |