Association between depression and young-onset dementia in middle-aged women

Table 3 Association between age at menarche and risk of young-onset dementia based on depression status

	Age at menarche (years)	Premenopausal women without depression					Premenopausal women with depression
	Age at menarche (years)	No.	Event	Person-years	IR^a	Model 4^b	No.	Event	Person-years	IR^a	Model 4^b
Any dementia
	≤ 12	40,544	57	375,859	0.15	0.94 (0.72, 1.23)	1,319	6	12,209	0.49	0.96 (0.42, 2.20)
	13–14	288,936	418	2,683,112	0.16	0.87 (0.77, 0.98)	8,912	54	82,685	0.65	1.12 (0.80, 1.57)
	15–16	419,801	862	3,901,204	0.22	1 (Ref.)	14,181	92	131,482	0.70	1 (Ref.)
	> 16	166,314	635	1,545,685	0.41	1.36 (1.22, 1.50)	6,924	71	64,123	1.11	1.16 (0.85, 1.59)
	P for trend					< 0.0001					0.574
Alzheimer’s dementia
	≤ 12	40,544	41	375,859	0.11	1.14 (0.83, 1.57)	1,319	4	12,209	0.33	0.89 (0.32, 2.43)
	13–14	288,936	255	2,683,112	0.10	0.89 (0.76, 1.03)	8,912	40	82,685	0.48	1.14 (0.77, 1.68)
	15–16	419,801	528	3,901,204	0.14	1 (Ref.)	14,181	69	131,482	0.52	1 (Ref.)
	> 16	166,314	430	1,545,685	0.28	1.46 (1.28, 1.66)	6,924	50	64,123	0.78	1.07 (0.74, 1.53)
	P for trend					< 0.0001					1
Vascular dementia
	≤ 12	40,544	9	375,859	0.02	0.54 (0.28, 1.06)	1,319	1	12,209	0.08	0.97 (0.13, 7.38)
	13–14	288,936	113	2,683,112	0.04	0.89 (0.71, 1.13)	8,912	9	82,685	0.11	1.15 (0.50, 2.66)
	15–16	419,801	212	3,901,204	0.05	1 (Ref.)	14,181	14	131,482	0.11	1 (Ref.)
	> 16	166,314	123	1,545,685	0.08	1.15 (0.91, 1.44)	6,924	15	64,123	0.23	1.72 (0.83, 3.58)
	P for trend					0.016					0.279

IR: incidence rate; Ref.: reference
^aPer 1,000 person-years
^bModel 4 was adjusted for age, smoking status, regular exercise, alcohol consumption, body mass index, hypertension, type 2 diabetes, dyslipidemia, chronic kidney disease, age at menarche, age at menopause, parity, breast feeding, oral contraceptive use, and hormone replacement therapy

ISSN: 1758-9193