Table 1 Baseline characteristics of the study cohort by cognitive stage. Table denotes mean ± standard deviation for continuous variables and frequency (percentage) for dichotomous variables

Demographics

Mean ± SD

n

Mean ± SD

n

N

Age, years

65 ± 8

140

72 ± 7.7

78

218

< 0.001

Gender, female

89 (64%)

140

36 (46%)

78

218

0.018

Education, years

16 ± 4

140

14 ± 4

78

218

0.002

MMSE

28.6 ± 1.4

140

26 ± 2.4

78

218

< 0.001

APOE carriers

36 (28%)

136

38 (49%)

68

204

< 0.001

Imaging

Mean ± SD

n

Mean ± SD

n

N

Hippocampal volume

7838 ± 788

75

6983 ± 996

71

146

< 0.001

Amyloid PET positivity

9 (25%)

36

39 (57%)

77

113

0.008

Amyloid Centiloid

14.5 ± 32.8

35

41.7 ± 42.8

68

103

0.002

Tau PET positivity

1 (3%)

36

24 (35%)

69

105

0.001

Tau Global SUVR

1.16 ± 0.14

23

1.32 ± 0.26

57

80

0.014

Plasma Biomarkers

Mean ± SD

n

Mean ± SD

n

N

Aβ42/Aβ40

0.064 ± 0.013

140

0.059 ± 0.013

78

218

0.009

p-tau181

13.2 ± 7

140

19.9 ± 10

78

218

< 0.001

p-tau231

7.8 ± 4.1

140

12.2 ± 6.1

78

218

< 0.001

NfL

15.8 ± 7.9

140

20.9 ± 9.3

78

218

< 0.001

GFAP

113 ± 55

140

187 ± 113

78

218

< 0.001