Table 3 Characteristics of the residents selected into the three cohorts matched on propensity scores. Cohort 1, 2 and 3 comprised residents exposed to acetylcholinesterase inhibitors (AChEI) only, memantine only, or AChEI plus memantine, respectively, and residents unexposed to anti-dementia drugs
Matched Cohort 1 | Matched Cohort 2 | Matched Cohort 3 | |||||||
|---|---|---|---|---|---|---|---|---|---|
None | AChEI | P | None | Memantine | P | None | AChEI plus memantine | P | |
(n = 3226) | (n = 1933) | (n = 2801) | (n = 1600) | (n = 717) | (n = 370) | ||||
Age, years (m, sd) | 84.8 (7.38) | 84.4 (6.42) | 0.027 | 85.6 (7.39) | 85.2 (6.24) | 0.050 | 83.9 (7.87) | 83.5 (6.56) | 0.358 |
Males (n,%) | 1,044 (31.97) | 602 (31.14) | 0.558 | 856 (30.56) | 494 (30.88) | 0.838 | 242 (33.75) | 117 (31.62) | 0.497 |
Level of dependency (n,%) | 0.840 | 0.658 | 0.640 | ||||||
very severe (GIR1) | 176 (5.39) | 109 (5.64) | 183 (6.53) | 124 (7.75) | 68 (9.48) | 34 (9.19) | |||
severe (GIR2) | 1,279 (39.16) | 754 (39.01) | 1,209 (43.16) | 671 (41.94) | 362 (50.49) | 167 (45.14) | |||
moderately severe (GIR3) | 793 (24.28) | 443 (22.92) | 688 (24.56) | 384 (24.00) | 123 (17.15) | 71 (19.19) | |||
moderate (GIR4) | 779 (23.85) | 487 (25.19) | 549 (19.60) | 324 (20.25) | 132 (18.41) | 78 (21.08) | |||
mild (GIR5) | 138 (4.23) | 79 (4.09) | 125 (4.46) | 67 (4.19) | 18 (2.51) | 11 (2.97) | |||
none (GIR6) | 101 (3.09) | 61 (3.16) | 47 (1.68) | 30 (1.88) | 14 (1.95) | 9 (2.43) | |||
MMSE score (m, sd) | 17.0 (7.29) | 17.3 (8.62) | 0.195 | 16.1 (7.44) | 16.2 (9.50) | 0.794 | 15.2 (7.73) | 15.5 (9.68) | 0.572 |
Charlson index (median, IQR) | 5 (4, 6) | 5 (4, 6) | 0.779 | 5 (5, 6) | 5 (5, 6) | 0.710 | 5 (4, 6) | 5 (5, 6) | 0.241 |