Table 4 Unadjusted and adjusted mortality hazard ratios and their 95% confidence intervals as a function of dementia drug exposure in the three matched cohorts. For each cohort, the hazard ratio was calculated using residents not exposed to anti-dementia drugs in the same cohort as a reference

Unadjusted

In matched cohort 1

Cholinesterase inhibitors only

0.853

(0.783 to 0.930)

< 0.001

In matched cohort 2

Memantine only

0.887

(0.810 to 0.970)

0.009

In matched cohort 3

Cholinesterase inhibitors plus memantine

0.780

(0.648 to 0.940)

0.009

Adjusted*

In matched cohort 1

Cholinesterase inhibitors only

0.870

(0.799 to 0.949)

0.002

In matched cohort 2

Memantine only

0.882

(0.806 to 0.966)

0.007

In matched cohort 3

Cholinesterase inhibitors plus memantine

0.778

(0.643 to 0.936)

0.008