Table 3 Pharmacokinetic parameters for Posiphen and metabolites in plasma

60 mg (n = 4)

60 mg BID (n = 5)

60 mg TID (n = 1)

Posiphen

AUC_0 − 24 (hr*ng/mL)

212.32 (18.14)

195.80 (69.26)

288.25

C_max (ng/mL)

52.70 (44.67)

30.39 (51.86)

51.80

T_max (hr)

2 (2–2)

2 (2–12)

2

t_1/2 (hr)

3.55 (48.65)

.

.

V/F (L)

1403.1 (59.23)

.

.

Cl/F (L/hr)

274.04 (17.50)

.

.

N1 metabolite

AUC_0 − 24 (hr*ng/mL)

36.60 (19.24)

65.06 (58.61)

60.18

C_max (ng/mL)

5.43 (21.98)

6.96 (32.01)

5.48

T_max (hr)

2 (2–4)

12 (2–20)

2

N8 metabolite

AUC_0 − 24 (hr*ng/mL)

66.02 (20.83)

113.65 (44.01)

80.40

C_max (ng/mL)

6.81 (25.10)

10.01 (27.79)

5.41

T_max (hr)

3 (3–4)

12 (2–20)

2