Table 3 Longitudinal brain age increase over time. Data represented as mean ± standard deviation (SD) or percentages (where applicable)
From: Brain age as a biomarker for pathological versus healthy ageing – a REMEMBER study
Disease stage | Brain age, BL | Brain age, FU | Brain age, p-value | BPAD, BL | BPAD, FU | BPAD, p-value | MMSE, BL | MMSE, last FU | Time between BL and FU MRI (years) | Time between BL and last FU MMSE(years) | Increase in brain age (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
HC (n = 15) | 65.67 (14.32) | 72.41 (17.41) | 0.037* | -0.145 (10.79) | 5.651 (12.82) | 0.051 | 29 (2) | 29 (3) | 1.5 (1.7) | 1.5 (1.0) | 10.3 |
SCD (n = 17) | 71.37 (17.60 | 74.28 (10.63) | 0.330 | 3.59 (14.14) | 4.93 (8.15) | 0.649 | 27 (2) | 27 (2) | 1.5 (1.0) | 2.0 (1.2) | 4.08 |
MCI (n = 60) | 86.69 (18.72) | 86.63 (17.02) | 0.976 | 14.31 (13.81) | 12.77 (13.34) | 0.407 | 26 (3) | 24 (5) | 1.5 (1.0) | 2.0 (1.2) | -0.07 |
ADD (n = 33) | 85.33 (24.23) | 89.36 (24.76) | 0.406 | 13.88 (22.72) | 16.31 (22.42) | 0.608 | 23 (3) | 21 (5) | 1.5 (1.0) | 1.9 (1.3) | 4.71 |
Total (n = 125) | 81.72 (21.04) | 83.96 (19.62) | 0.174 | 11.01 (17.12) | 11.78 (16.08) | 0.631 | 26 (3) | 24 (5) | 1.5 (1.1) | 1.9 (1.2) | 1.49 |