Fig. 1

The landscape of disease-causing genes of FTD and ALS. Some FTD-causing genes overlap with ALS genes. The position of a gene depends on when it was discovered and how specifically it is associated with the clinical phenotypes of ALS (yellow) and FTD (green). The timelines of the genes discovered are shown in the Y axis. Genes are plotted according to their hypothesized mechanism in relation to disease. The size of a gene icon depends on the frequency of its occurrence and its clinical and functional significance