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Table 1 Demographic data of FTD patients

From: Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations

 

Overall

Sporadic FTD

Familial FTD

bvFTD

svPPA

nvPPA

FTD-ALS

FTD-P

Cases, n

261

229 (87.7%)

32 (12.3%)

185 (70.9%)

40(15.3%)

14(5.4%)

9(3.5%)

13(5.0%)

Female, n (%)

144 (55.2%)

129 (56.3%)

15 (46.9%)

103 (55.7%)

21 (52.1%)

8 (57.1%)

5 (55.6%)

7 (53.8%)

Age (years)

60.2 ± 10.6

61.3 ± 10.4

54.5 ± 3.0

61.7 ± 8.9

59.3 ± 4.5

59.6 ± 4.1

62.8 ± 2.2

63.4 ± 2.7

AAO (years)

57.7 ± 10.9

58.8 ± 10.1

52.6 ± 3.0

58.8 ± 8.6

57.2 ± 4.5

56.6 ± 4.4

61.0 ± 2.4

59.5 ± 2.8

Early-onset n (%)

237 (90.8%)

207 (90.4%)

30 (93.8%)

169 (91.4%)

37 (92.5%)

14 (100%)

8 (88.9%)

9 (69.2%)

Minimum disease durationa (years)

2.6 ± 1.8

2.5 ± 1.8

2.0 ± 1.7

2.8 ± 1.9

2.1 ± 1.6

3.1 ± 2.0

1.9 ± 1.8

3.9 ± 2.2

MMSE score

17.8 ± 6.9

18.0 ± 6.6

16.8 ± 6.3

17.6 ± 6.7

15.6 ± 5.2

15.4 ± 4.7

20.2 ± 3.6

18.4 ± 2.3

MoCA score

11.5 ± 6.4

12.2 ± 6.1

10.5 ± 5.7

11.0 ± 6.2

9.9 ± 5.6

10.5 ± 4.9

15.6 ± 4.1

12.4 ± 1.8

Genetically diagnosed

61 (23.4%)

44 (19.2%)

17 (53.1%)

42 (22.7%)

9 (22.5%)

0

4 (44.4%)

6 (46.2%)

  1. FTD frontotemporal dementia, bvFTD behavioral variant of FTD, nvPPA nonfluent/agrammatic variant primary progressive aphasia, svPPA semantic variant primary progressive aphasia, ALS amyotrophic lateral sclerosis, FTD-P FTD-parkinsonism overlap, AAO age at onset
  2. aMinimum disease duration is the span of time from the onset of the disease to the last follow-up in most cases of our cohort