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Table 3 Association of MASLD, SLD subtypes with all-cause and cause-specific dementia

From: Association of MAFLD and MASLD with all-cause and cause-specific dementia: a prospective cohort study

 

No. of participants

No. of cases (%)

Crude modela

Multivariable model 1b

Multivariable model 2c

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

All-cause dementia

        

MASLD–

291,568

3,808 (1.31)

Reference

-

Reference

-

Reference

-

MASLD+

111,938

1,924 (1.72)

1.34 (1.27, 1.42)

< 0.0001

1.09 (1.03, 1.15)

0.0046

1.05 (0.99, 1.11)

0.1173

No SLD

247,986

3,197 (1.29)

Reference

-

Reference

-

Reference

-

MASLD

111,938

1,924 (1.72)

1.37 (1.29, 1.45)

< 0.0001

1.09 (1.03, 1.16)

0.0037

1.05 (0.99, 1.11)

0.1382

MetALD

43,528

610 (1.4)

1.12 (1.03, 1.22)

0.0106

1.03 (0.94, 1.13)

0.5291

0.99 (0.91, 1.09)

0.8581

Cryptogenic SLD

30

0 (0.00)

-

-

-

-

-

-

Other specific etiology SLD

24

1 (4.17)

4.32 (0.61, 30.7)

0.1437

6.86 (0.97, 48.8)

0.0542

5.17 (0.73, 36.8)

0.1005

Alzheimer’s disease

        

MASLD–

291,568

1,609 (0.55)

Reference

-

Reference

-

Reference

-

MASLD+

111,938

746 (0.67)

1.23 (1.13, 1.34)

< 0.0001

1.02 (0.93, 1.11)

0.7405

1.00 (0.91, 1.09)

0.9122

No SLD

247,986

1,409 (0.57)

Reference

-

Reference

-

Reference

-

MASLD

111,938

746 (0.67)

1.20 (1.10, 1.31)

< 0.0001

0.99 (0.9, 1.08)

0.7709

0.96 (0.88, 1.06)

0.4151

MetALD

43,528

200 (0.46)

0.83 (0.72, 0.97)

0.0152

0.80 (0.69, 0.93)

0.0044

0.79 (0.67, 0.92)

0.0019

Cryptogenic SLD

30

0 (0.00)

-

-

-

-

-

-

Other specific etiology SLD

24

0 (0.00)

-

-

-

-

-

-

Vascular dementia

        

MASLD–

291,568

772 (0.26)

Reference

-

Reference

-

Reference

-

MASLD+

111,938

502 (0.45)

1.73 (1.54, 1.93)

< 0.0001

1.34 (1.19, 1.50)

< 0.0001

1.24 (1.10, 1.39)

0.0003

No SLD

247,986

601 (0.24)

Reference

-

Reference

-

Reference

-

MASLD

111,938

502 (0.45)

1.89 (1.68, 2.13)

< 0.0001

1.43 (1.26, 1.62)

< 0.0001

1.32 (1.16, 1.49)

< 0.0001

MetALD

43,528

170 (0.39)

1.66 (1.40, 1.97)

< 0.0001

1.42 (1.19, 1.70)

0.0001

1.33 (1.12, 1.59)

0.0015

Cryptogenic SLD

30

0 (0.00)

-

-

-

-

-

-

Other specific etiology SLD

24

1 (4.17)

22.8 (3.21, 162.2)

0.0018

36.1 (5.06, 257.1)

0.0003

21.5 (3.01, 153.5)

0.0022

  1. HR, hazard ratio; MASLD, metabolic dysfunction-associated steatotic liver disease; MetALD, MASLD with greater alcohol consumption; SLD, steatotic liver diseases
  2. aAnalysis by Cox proportional hazards model
  3. bAdjusted for age, sex, ethnicity, education, Townsend deprivation index, income levels, smoking status, alcohol intake and IPAQ activity group
  4. cAdditionally adjusted for APOE ε4 genotypes and cardiovascular diseases
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Alzheimer's Research & Therapy

ISSN: 1758-9193