Fig. 4
For the low beta-amyloid sample, lower LC MRI signal intensity is associated with lower entorhinal cortical thickness, particularly in individuals with elevated EC FTP.Associations between measures of cortical thickness and LC MRI signal intensity interacted with EC FTP for the low beta-amyloid sample, corrected for age, sex, and years of education. A Positive association and corresponding test statistic between CT region (entorhinal cortex) and the interaction of EC FTP with LC MRI signal intensity. B Visualization of the association between CT of the Braak I-II region (n = 112; PFDR = .004) and EC FTP interacted with LC MRI signal intensity for the low beta-amyloid sample: lower LC MRI signal intensity is associated with lower CT in early Braak I-II region, particularly in individuals with elevated EC FTP. LC MRI signal intensity is shown at simple slopes representing minimum, median, and maximum for visualization, but analyses have been conducted continuously. Shaded areas represent the 95% confidence interval. Abbreviations: LC, locus coeruleus; CT, cortical thickness