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Table 1 Characteristics of participants sorted on PiB status

From: Lower in vivo locus coeruleus integrity is associated with lower cortical thickness in older individuals with elevated Alzheimer’s pathology: a cohort study

Characteristics of participants sorted on PiB status

 

Low beta-amyloid

Elevated beta-amyloid

P-value

n

112

53

 

Age

71.85 (9.67)

79.30 (7.74)

 < 0.001 **

Sex, No. (%) = M

45 (40.2)

22 (41.5)

1.000

Years of Education

16.31 (2.87)

16.42 (2.92)

0.832

Race, No. (%)

  

0.994

 AS

3 (2.7)

1 (1.9)

 

 B

12 (10.7)

6 (11.5)

 

 NH

17 (15.2)

8 (15.4)

 

 Other

2 (1.8)

1 (1.9)

 

 Unknown

4 (3.6)

1 (1.9)

 

 W

74 (66.1)

35 (67.3)

 

APOE-ε4 Carrier Status, No. (%) = ε4+ 

13 (12.0)

27 (52.9)

 < 0.001 **

LC MRI signal intensity

1.34 (0.05)

1.30 (0.03)

 < 0.001 **

IT FTP values (SUVr, PVC)

1.41 (0.16)

1.66 (0.42)

 < 0.001 **

EC FTP values (SUVr, PVC)

1.28 (0.26)

1.56 (0.43)

 < 0.001 **

FLR-PiB values (DVR, PVC)

1.19 (0.06)

1.93 (0.47)

 < 0.001 **

Clinical Dementia Rating, No. (%)

  

0.017 *

 0

106 (94.6)

43 (81.1)

 

 0.5

6 (5.4)

9 (17.0)

 

 1

0 (0.0)

1 (1.9)

 

MMSE Score

29.04 (1.26)

28.08 (1.99)

 < 0.001 **

  1. Data is presented as numbers and (percentages) or means and (standard deviations). Chi-square tests and Kruskal tests were conducted to reveal group differences for categorical and non-normal continuous variables, respectively. Missing data for Race (n = 1) and APOE-ε4 Carrier Status (n = 6). Abbreviations: No, number; M, male; AS, Asian; B, Black or African American; NH, Native Hawaiian or other Pacific Islander; W, White; LC, locus coeruleus; IT, inferior temporal; FTP, [18F]-flortaucipir; SUVr, standardized uptake value ratio; PVC, partial-volume corrected; EC, entorhinal cortex; FLR, frontal, laterotemporal and retrosplenial cortices; PiB, [11C]-Pittsburgh Compound-B; DVR, distribution volume ratio; MMSE, Mini-Mental State Examination. *P < .05; **P < .001