Fig. 4

Functional connectivity results. Increase (A) and decrease (B) of functional connectivity in the PC-rTMS as compared to the Sham group after 24 weeks of stimulation are shown. The analysis was performed using the PC as seed. (C) & (D) represent the network mapping results showing the belonging of the positive cluster (the precuneus cortex) to the DMN (in the red squares) and of the negative cluster (the left superior parietal lobule) to the DAN (in the blue squares). Images are shown in neurological convention. (E) The significant correlation between FC (both positive and negative clusters) and GM changes (pre-post) after 24 weeks of PC-rTMS is shown. No correlation was found among the changes of FC over the SPL and GM changes