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Table 1 Cohort characteristics and plasma biomarkers levels

From: Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies

 

NC

DLB

AD

 

n total = 207

n = 27

n = 104

n = 76

P-value

Age, year

61.3 [10.0]

71.2 [11.4]

72.1 [11.8]

< 0.001a

Sex, male

41% (11)

59% (61)

41% (31)

0.037b

APOE ɛ4 carriership

32% (8/25)

39% (31/79)

68% (47/69)

< 0.001b

MMSE

28.5 [3.00]

25.0 [5.75]

19.0 [5.50]

< 0.001a

Level of education, year

15.0 [5.00]

11.0 [6.00]

11.0 [6.00]

0.002a

CSF biomarkers, ATN

   

< 0.001a

Available (n)

100% (27)

87% (90)

100% (76)

 

A-T-

100% (27)

59% (53)

0% (0)

 

A + T-

0% (0)

17% (15)

3% (2)

 

A + T+

0% (0)

12% (11)

97% (74)

 

A-T+

0% (0)

12% (11)

0% (0)

 

Plasma biomarkers

    

Plasma Aβ40/Aβ42 ratio

0.0646 [0.0140]

0.0589 [0.0181]

0.0534 [0.0154]

< 0.001

Plasma GFAP, pg/mL

59.4 [35.3]

107 [81.5]

157 [112]

< 0.001

Plasma NfL, pg/mL

17.2 [7.95]

21.5 [14.0]

25.3 [12.7]

< 0.001

Plasma p-tau181, pg/mL

1.62 [0.788]

2.03 [1.52]

3.81 [1.79]

< 0.001

Plasma sTREM2, pg/mL

444 [274]

629 [397]

518 [415]

0.029

Plasma YKL-40, ng/mL

73.7 [75.3]

87.7 [103]

79.2 [62.4]

0.091

  1. Continuous variables are presented as median [IQR] and categorical data as number (%)
  2. aAge, MMSE scores, and level of education were compared between groups using the Kruskall-Wallis test. bAPOE ɛ4 carriership frequency and ATN profiles were compared between groups using Chi2 test. In-between groups comparison of plasma biomarker levels was performed using one-way ANCOVA adjusted on age and sex
  3. Abbreviations: AD, Alzheimer’s disease; APOE, apolipoprotein E, CSF, cerebrospinal fluid, DLB, dementia with Lewy bodies; GFAP, glial fibrillary acidic protein; NC, neurological controls; MMSE, mini-mental state examination; NfL, neurofilament light chain; p-tau181, tau phosphorylated at serine 181; sTREM2, soluble triggering receptor expressed myeloid cells 2
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Alzheimer's Research & Therapy

ISSN: 1758-9193