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Table 2 CSF biomarker concentrations in samples collected in the morning and evening

From: Effects of time of the day at sampling on CSF and plasma levels of Alzheimer’ disease biomarkers

Biomarkers

Morning concentration

Evening concentration

Differences evening-morning

% Change

F (df1, df2) a

P-value corrected (uncorrected) b

Aβ42 [ng/mL]

1.53 (0.85)

1.74 (0.82)

0.21 (0.35 to 0.07)

17.02 (9.99 to 24.06)

8.99 (1, 37)

0.038 (0.005)

Aβ40 [ng/mL]

19.08 (4.44)

20.94 (4.86)

1.85 (1.09 to 2.62)

10.46 (6.50 to 14.42)

24.10 (1, 37)

0.0008 (0.0001)

Aβ42/Aβ40 ratio

0.081 (0.03)

0.085 (0.04)

0.004 (0.001 to 0.008)

5.29 (1.57 to 9.01)

5.91 (1, 37)

0.16 (0.02)

P-tau217 [pg/mL]

14.50 (19.66)

15.52 (22.61)

1.02 (-0.06 to 2.10)

4.03 (0.81 to 7.25)

3.67 (1, 37)

0.50 (0.06)

P-tau231 [pg/mL]

269.54 (176.24)

272.73 (184.1)

7.84 (2.11 to 13.56)

2.60 (0.48 to 4.72)

7.71 (1, 36) c

0.07 (0.009)

P-tau181 [pg/mL]

466.51 (669.2)

472.96 (687.58)

14.83 (3.76 to 25.90)

2.80 (0.94 to 4.66)

7.38 (1, 36) c

0.08 (0.01)

GFAP [pg/mL]

13.76 (5.22)

14.25 (5.92)

0.49 (0.03 to 0.95)

2.59 (-0.64 to 5.83)

4.62 (1, 37)

0.30 (0.04)

NfL [ng/mL]

184.92 (84.22)

179.58 (76.04)

-5.33 (-6.52 to 17.18)

-1.54 (-5.19 to 2.12)

0.83 (1, 37)

1 (0.37)

  1. Data shown as mean (SD) or mean (95%CI) unless specified otherwise. Abbreviations: CSF, cerebrospinal fluid; Aβ, amyloid beta; GFAP, glial fibrillary acidic protein; NfL, neurofilament light; P-tau, phosphorylated tau
  2. a Main effects of sampling time from repeated measures two-way ANOVA
  3. bP-values were corrected for multiple comparison using the Bonferroni-Dunn method
  4. c Data was missing for 1 participant
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Alzheimer's Research & Therapy

ISSN: 1758-9193