Table 3 Plasma biomarker concentration in samples collected in the morning and evening
From: Effects of time of the day at sampling on CSF and plasma levels of Alzheimer’ disease biomarkers
Plasma Biomarkers [units] | Morning concentration | Evening concentration | Differences evening-morning | % Change | F (df1, df2) a | P-value corrected (uncorrected) b |
|---|---|---|---|---|---|---|
Aβ42 [pg/mL] | 38.43 (7.76) | 40.08 (7.37) | 1.65 (0.84 to 2.47) | 4.84 (2.68 to 7) | 16.81 (1, 37) | 0.002 (0.0002) |
Aβ40 [ng/mL] | 0.29 (0.05) | 0.30 (0.05) | 0.01 (0.006 to 0.02) | 4.24 (2.15–6.32) | 16.05 (1, 37) | 0.002 (0.0003) |
Aβ42/40 | 0.14 (0.03) | 0.14 (0.03) | 0.001 (-0.002 to 0.001) | 0.65 (-0.70 to 1.10) | 0.79 (1, 37) | 1 (0.38) |
P-tau217 [pg/mL] | 0.37 (0.16) | 0.36 (0.16) | -0.01 (-0.01 to 0.03) | -0.56 (-7.13 to 6.01) | 0.95 (1, 37) | 1 (0.34) |
P-tau231 [pg/mL] | 6.88 (3.05) | 6.67 (3) | -0.22 (-0.52 to 0.95) | 2.48 (-8.86 to 13.83) | 0.35 (1, 35) c | 1 (0.55) |
P-tau181 [pg/mL] | 10.61 (4.89) | 9.94 (4.43) | -0.71 (-0.76 to 2.10) | -0.15 (-11.75 to 11.46) | 0.90 (1, 37) | 1 (0.35) |
GFAP [pg/mL] | 0.11 (0.07) | 0.10 (0.05) | -0.01 (-0.004 to 0.02) | -1.81 (-10.03 to 6.40) | 2.04 (1, 37) | 1 (0.16) |
NfL [ng/mL] | 3.83 (2.10) | 3.42 (1.47) | -0.41 (-0.12 to 0.94) | -3.96 (-11.75 to 3.82) | 2.46 (1, 37) | 1 (0.13) |