Table 4 CSF synaptic and endo-lysosomal biomarkers with increased levels in samples collected in the evening vs. morning
From: Effects of time of the day at sampling on CSF and plasma levels of Alzheimer’ disease biomarkers
Biomarkers | Morning concentration (fmol/µl) | Evening concentration (fmol/µl) | Differences evening-morning | % Change | F (df1, df2)a | P-value corrected (uncorrected) b |
|---|---|---|---|---|---|---|
Synaptic panel | ||||||
Amyloid Precursor Protein | 3.80 (1.32) | 4.04 (1.41) | 0.24 (0.12 to 0.37) | 7.06 (4.02 to 10.10) | 15.46 (1, 37) | 0.005 (0.0004) |
Syntaxin-1B | 0.31 (0.10) | 0.34 (0.11) | 0.02 (0.01 to 0.03) | 7.10 (3.38 to 10.81) | 13.77 (1, 37) | 0.005 (0.0007) |
Neuronal pentraxin receptor | 1.22 (0.55) | 1.35 (0.60) | 0.12 (0.05 to 0.19) | 12.15 (6.15 to 18.15) | 13.58 (1, 37) | 0.005 (0.0007) |
Neuronal pentraxin-1 | ||||||
ETVLQQK LTPGEVYNLATCSTK | 0.67 (0.24) 1.52 (0.46) | 0.71 (0.26) 1.61 (0.49) | 0.04 (0.01 to 0.07) 0.09 (0.04 to 0.14) | 7.66 (3.28 to 12.04) 6.24 (3.02 to 9.47) | 8.38 (1, 37) 11.92 (1, 37) | 0.020 (0.006) 0.008 (0.001) |
Neurogranin | 0.60 (0.28) | 0.66 (0.31) | 0.06 (0.02 to 0.10) | 11.59 (6.64 to 16.54) | 10.56 (1, 37) | 0.012 (0.003) |
β-synuclein | 0.28 (0.10) | 0.30 (0.12) | 0.03 (0.04 to 0.007) | 9.59 (3.90 to 15.28) | 7.91 (1, 37) | 0.020 (0.008) |
γ-synuclein | 0.60 (0.21) | 0.64 (0.20) | 0.13 (0.001 to 0.26) | 8.50 (3.31 to 13.70) | 5.82 (1, 37) | 0.042 (0.021) |
PEBP- 1 | 7.91 (2.43) | 8.23 (2.57) | 0.32 (0.10 to 0.54) | 4.45 (1.71 to 7.20) | 8.96 (1, 37) | 0.020 (0.005) |
14-3-3ε | 0.43 (0.14) | 0.45 (0.16) | 0.03 (0.01 to 0.05) | 6.62 (2.29 to 10.96) | 8.05 (1, 37) | 0.020 (0.007) |
Chromogranin-A | 4.04 (2.82) | 4.38 (2.99) | 0.34 (0.10 to 0.57) | 9.38 (4.97 to 13.78) | 8.2 (1, 37) | 0.020 (0.007) |
Secretogranin-2 | 4.10 (1.55) | 4.36 (1.74) | 0.26 (0.06 to 0.47) | 7.06 (2.65–11.47) | 6.75 (1, 37) | 0.030 (0.013) |
Neurosecretory protein VGF | ||||||
NSEPQDEGELFQGVDPR AYQGVAAPFPK | 3.77 (2.00) 7.52 (4.02) | 3.98 (2.13) 8.08 (4.49) | 0.21 (0.03 to 0.38) 0.56 (0.14 to 0.98) | 6.38 (1.89 to 10.88) 8.45 (3.47 to 13.43) | 5.84 (1, 37) 7.41 (1, 37) | 0.041 (0.021) 0.023 (0.010) |
Endo-lysosomal panel | ||||||
Ganglioside GM2 activator | ||||||
EVAGLWIK ESVLSSSGK | 3.91 (1.45) 5.38 (1.95) | 4.11 (1.49) 5.60 (2.01) | 0.20 (0.10 to 0.30) 0.23 (0.11 to 0.35) | 5.95 (2.94 to 8.96) 4.70 (2.27 to 7.13) | 15.87 (1, 37) 14.15 (1, 37) | 0.005 (0.0003) 0.005 (0.0006) |
Cathepsin F | 0.45 (0.13) | 0.49 (0.13) | 0.04 (0.01 to 0.07) | 13.29 (4.44 to 22.14) | 7.97 (1, 37) | 0.020 (0.008) |