The longitudinal trajectory of CSF sTREM2: the alzheimer’s disease neuroimaging initiative

Table 1 Annual change rates of CSF sTREM2 by baseline age interval and consecutive slope difference using baseline and longitudinal data, ADNI cohort, United States and Canada, 2004–2021

Baseline age interval	Size/ observations	Mean^a	Slope^b	Se^c	P^d	Slope difference (β (P value))^e	Mean^a	Slope^b	Se^c	P^d	Slope difference (β (P value))^e
		Baseline data (CN)^f					Longitudinal data (CN)^g
50–64	11/19	2678.68	162.54	143.08	0.285	-	2566.85	157.89	86.55	0.090	-
65–74	173/294	3722.57	30.27	49.43	0.541	-132.27 (0.560)	3935.93	90.11	31.24	0.004	-75.73 (0.581)
≥ 75	121/247	4674.34	161.75	57.00	0.005	131.48 (0.079)	4994.55	151.48	39.07	< 0.001	60.65 (0.223)
		Baseline data (MCI)^f					Longitudinal data (MCI)^g
50–64	93/165	3161.63	61.99	60.06	0.305	-	3356.53	182.46	38.30	< 0.001	-
65–74	228/433	3965.49	22.03	45.73	0.630	-39.96 (0.633)	4235.47	151.70	28.81	< 0.001	-32.21 (0.531)
≥ 75	198/345	4420.29	126.01	46.71	0.008	103.98 (0.116)	4812.92	150.34	35.79	< 0.001	-2.91 (0.949)
		Baseline data (dementia)^f					Longitudinal data (dementia)^g
50–64	34/37	3230.83	127.94	81.79	0.128	-	3213.05	100.58	76.55	0.198	-
65–74	56/77	3783.69	101.74	105.23	0.338	-26.21 (0.854)	3752.38	68.61	85.41	0.424	-33.42 (0.784)
≥ 75	103/135	4619.19	125.95	51.42	0.016	24.22 (0.842)	4723.13	137.52	49.18	0.006	52.80 (0.611)
		Baseline data (entire sample)^f					Longitudinal data (entire sample)^g
50–64	138/221	3140.18	82.42	46.14	0.076	-	3268.37	167.04	32.26	< 0.001	-
65–74	457/804	3851.25	33.02	31.84	0.300	-49.40 (0.443)	4079.45	125.93	20.57	< 0.001	-44.10 (0.293)
≥ 75	422/727	4541.68	133.38	29.43	< 0.001	100.36 (0.023)	4859.65	145.90	23.29	< 0.001	27.12 (0.389)
Total	1072/1752	4041.26	77.26	8.68	< 0.001		4362.55	90.81	7.91	< 0.001

^aMean: the mean value of CSF sTREM2 levels within the baseline age interval, pg/ml
^bSlope: the annual rate of change in sTREM2 levels within the baseline age interval, pg/(ml·year)
^cSe: the standard error of the annual rate of change in sTREM2 levels within the baseline age interval, pg/(ml·year)
^dP: the P value of the annual rate of change in sTREM2 levels within the baseline age interval
^eSlope difference (β (P value)): the difference in annual rates of change in sTREM2 levels between the older age interval and the prior younger age interval, pg/(ml·year²)
^fAll multivariate linear regression models had no adjustment for covariates
^gAll linear mixed-effect models included age as fixed effects with an additional random slope and intercept for age
Abbreviations CN, cognitively normal; MCI, mild cognitive impairment; CSF, cerebrospinal fluid; sTREM2, soluble TREM2; β, regression coefficient; Se, standard deviation

ISSN: 1758-9193