Fig. 1

Hormone therapy mitigates NFT load and p-tau concentrations in post-menopausal females. HT+ females demonstrated significantly lower tau-PET SUVRs in Braak I-II ROIs (TRIAD: P < 0.05, Hedges’ g = 0.73), Braak III-IV ROIs (TRIAD: P < 0.0001, Hedges’ g = 0.74; ADNI: P < 0.01, Hedges’ g = 0.45) and Braak V-VI ROIs (TRIAD: P < 0.0001, Hedges’ g = 0.69; ADNI: P < 0.01, Hedges’ g = 0.37) compared to HT- females. HT + females also showed significantly lower CSF p-tau181 (P < 0.001) and plasma p-tau181 (P < 0.0001) concentrations