Fig. 2

Hormone therapy use is linked to lower regional tau load in post-menopausal females. (A) Results from voxel-based Welch’s t-test showed that HT + females presented significantly lower tau-PET SUVR in multiple brain regions as demonstrated in the t-statistical map. (B) Among cognitively impaired subjects, HT + females also demonstrated significantly less NFT load compared to HT- females. (C) In post-menopausal HT non-users, APOEε4 carriers presented with significantly higher NFT load compared to APOEε4 non-carriers. In contrast, post-menopausal females who use HT showed similar levels of tau-PET signals, regardless of their APOE genotypes. Images represent voxel-based t-statistical parametric maps overlaid on the structural MRI reference template. Results were corrected for multiple comparisons using the FDR cluster threshold of P < 0.001