Table 4 Multivariable-adjusted associations of CAA diagnosis with the number and severity of NPS.
Number of NPS | NPS total severity | |||
|---|---|---|---|---|
Incidence rate ratio (95% CI) | p-value | Estimate (95% CI) | p-value | |
Step 1 | ||||
CAA diagnosis Age Female Years of education | 6.07 (3.15 to 11.69) 1.05 (1.01 to 1.09) 1.31 (0.76 to 2.26) 0.98 (0.89 to 1.08) | < 0.001 0.009 0.324 0.738 | 3.32 (1.86 to 4.79) 0.10 (0.02 to 0.18) 0.56 (-0.64 to 1.78) -0.01 (-0.22 to 0.19) | < 0.001 0.015 0.355 0.913 |
Step 2 | ||||
CAA diagnosis Age Female Years of education Arterial hypertension | 6.03 (2.99 to 12.19) 1.05 (1.01 to 1.09) 1.31 (0.76 to 2.26) 0.98 (0.89 to 1.08) 1.01 (0.47 to 2.18) | < 0.001 0.009 0.323 0.743 0.964 | 3.36 (1.78 to 4.94) 0.10 (0.02 to 0.18) 0.56 (-0.66 to 1.78) -0.01 (-0.22 to 0.19) -0.11 (-1.83 to 1.61) | < 0.001 0.016 0.366 0.902 0.898 |
Step 3 | ||||
CAA diagnosis Age Female Years of education Arterial hypertension AD pathology | 4.43 (1.97 to 9.94) 1.05 (1.01 to 1.09) 1.28 (0.74 to 2.20) 0.98 (0.89 to 1.07) 1.09 (0.51 to 2.34) 1.15 (0.50 to 2.64) | < 0.001 0.009 0.366 0.720 0.816 0.726 | 3.34 (1.75 to 4.92) 0.09 (0.01 to 0.18) 0.57 (-0.65 to 1.80) -0.01 (-0.22 to 0.19) -0.06 (-1.79 to 1.66) 0.74 (-1.13 to 2.62) | < 0.001 0.025 0.355 0.883 0.944 0.433 |
Step 4 | ||||
CAA diagnosis Age Female Years of education Arterial hypertension AD pathology | 4.86 (2.20 to 10.73) 1.05 (1.01 to 1.08) 1.26 (0.74 to 2.13) 0.98 (0.89 to 1.07) 1.08 (0.52 to 2.26) 1.50 (0.62 to 3.57) | < 0.001 0.009 0.380 0.746 0.823 0.360 | 3.56 (1.94 to 5.19) 0.09 (0.00 to 0.18) 0.58 (-0.65 to 1.82) 0.00 (-0.22 to 0.21) -0.08 (-1.81 to 1.65) 1.10 (-0.92 to 3.13) | < 0.001 0.031 0.349 0.972 0.927 0.281 |
APOE status | ||||
Ho/he APOEε4 Ho/he APOEε2 APOEε4 and APOEε2 | 0.48 (0.26 to 0.90) 0.51 (0.22 to 1.22) 1.52 (0.36 to 6.30) | 0.022 0.135 0.562 | -0.90 (-2.45 to 0.63) -1.01 (-3.17 to 1.13) 0.41 (-3.01 to 3.85) | 0.247 0.350 0.809 |