Table 2 Associations of ChP volume, hippocampal volume, LVV, ECT alone, and combined ChP and hippocampal volumes with the neuropsychological tests in patients in the AD continuum at baseline
From: Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer’s continuum
Imaging markers | Outcomes | β value* | 95% CI | t value | P value | Outcomes | β value* | 95% CI | t value | P value |
|---|---|---|---|---|---|---|---|---|---|---|
Model 1: only included one neuroimaging measure | ||||||||||
ChP alone | MMSE score | -0.32 | -5.25 × 10− 3 to -2.99 × 10− 3 | -7.15 | < 0.001 | NPI score | 0.23 | 3.28 × 10− 3 to 8.84 × 10− 3 | 4.51 | < 0.001 |
HIP alone | 0.45 | 2.02 × 10− 3 to 3.01 × 10− 3 | 10.02 | < 0.001 | -0.19 | -3.56 × 10− 3 to -1.10 × 10− 3 | -3.73 | < 0.001 | ||
LVV alone | -0.52 | -2.51 × 10− 4 to -1.81 × 10− 4 | -12.05 | < 0.001 | 0.32 | 1.97 × 10− 4 to 3.75 × 10− 4 | 6.34 | < 0.001 | ||
ECT alone | 0.46 | 6.29 to 8.89 | 11.48 | < 0.001 | -0.24 | -11.60 to -5.05 | -4.99 | < 0.001 | ||
ChP alone | MoCA score | -0.34 | -5.31 × 10− 3 to -3.15 × 10− 3 | -7.70 | < 0.001 | ADL score | 0.31 | 4.08 × 10− 3 to 7.58 × 10− 3 | 6.53 | < 0.001 |
HIP alone | 0.47 | 2.16 × 10− 3 to 3.09 × 10− 3 | 11.09 | < 0.001 | -0.40 | -4.08 × 10− 3 to -2.52 × 10− 3 | -8.32 | < 0.001 | ||
LVV alone | -0.52 | -2.43 × 10− 4 to -1.76 × 10− 4 | -12.23 | < 0.001 | 0.58 | 2.99 × 10− 4 to 4.05 × 10− 4 | 13.03 | < 0.001 | ||
ECT alone | 0.45 | 6.13 to 8.62 | 11.67 | < 0.001 | -0.44 | -12.90 to -8.83 | -10.5 | < 0.001 | ||
Model 2: both of ChP and hippocampal volume together | ||||||||||
ChP | MMSE score | -0.23 | -4.05 × 10− 3 to -1.88 × 10− 3 | -5.38 | < 0.001 | NPI score | 0.19 | 2.49 × 10− 3 to 7.98 × 10− 3 | 3.75 | < 0.001 |
HIP | 0.39 | 1.70 × 10− 3 to 2.68 × 10− 3 | 8.73 | < 0.001 | -0.15 | -3.01 × 10− 3 to -5.17 × 10− 4 | -2.78 | 0.006 | ||
ChP | MoCA score | -0.24 | -4.04 × 10− 3 to -2.01 × 10− 3 | -5.84 | < 0.001 | ADL score | 0.23 | 2.63 × 10− 3 to 6.07 × 10− 3 | 4.96 | < 0.001 |
HIP | 0.41 | 1.83 × 10− 3 to 2.76 × 10− 3 | 9.73 | < 0.001 | -0.34 | -3.61 × 10− 3 to -2.04 × 10− 3 | -7.09 | < 0.001 | ||
Model 3: both of ChP, HIP, and CHP*HIP together | ||||||||||
ChP | MMSE score | -0.25 | -0.01 to 0.01 | -1.26 | 0.208 | NPI score | 0.15 | -0.01 to 0.02 | 0.66 | 0.508 |
HIP | 0.38 | 4.98 × 10− 4 to 3.76 × 10− 3 | 2.57 | 0.011 | -0.17 | -6.22 × 10− 3 to 2.02 × 10− 3 | -1.00 | 0.318 | ||
ChP*HIP | 0.02 | 6.39 × 10− 7 to 6.92 × 10− 7 | 0.08 | 0.002 | 0.04 | 1.54 × 10− 6 to 1.82 × 10− 6 | 0.17 | 0.867 | ||
ChP | MoCA score | 0.12 | -6.07 × 10− 3 to 3.16 × 10− 3 | 0.62 | 0.536 | ADL score | 0.31 | -0.01 to 0.14 | 1.45 | 0.147 |
HIP | 0.51 | 1.27 × 10− 3 to 4.33 × 10− 3 | 3.60 | < 0.001 | -0.28 | -4.95 × 10− 3 to 2.24 × 10− 4 | 1.79 | 0.073 | ||
ChP*HIP | -0.15 | 8.41 × 10− 7 to 4.06 × 10− 7 | 0.69 | 0.493 | -0.09 | -1.25 × 10− 6 to 8.57 × 10− 7 | -0.37 | 0.713 | ||