Table 3 Joint effect of cardiometabolic diseases (CMDs) and cognitive reserve (CR) level: results from Cox and Laplace regression models
From: High cognitive reserve attenuates the risk of dementia associated with cardiometabolic diseases
Joint Exposure | No. of subjects | Hazard ratio of dementia (95% CI) | Â | Difference in time (years) to dementia diagnosis (95% CI) | Â | Population attributable fraction (95% CI) | |||
|---|---|---|---|---|---|---|---|---|---|
CMDs | CR level | Basic Adjusted | Multi-Adjusted | Â | Basic Adjusted | Multi-Adjusted | Â | ||
CMD-free | High | 58,738 | Reference | Reference | Â | Reference | Reference | Â | Â |
CMD-free | Moderate | 70,493 | 1.20 (1.11–1.29) | 1.15 (1.07–1.24) |  | -0.46 (-0.66, -0.26) | -0.37 (-0.59, -0.16) |  |  |
CMD-free | Low | 43,545 | 1.49 (1.38–1.61) | 1.37 (1.27–1.48) |  | -1.05 (-1.28, -0.82) | -0.86 (-1.10, -0.62) |  |  |
CMDs | High | 11,191 | 1.90 (1.70–2.11) | 1.83 (1.64–2.04) |  | -1.64 (-1.94, -1.35) | -1.70 (-2.06 -1.34) |  | 0.11 (0.04–0.18) |
CMDs | Moderate | 16,778 | 2.13 (1.94–2.33) | 1.97 (1.80–2.17) |  | -2.16 (-2.49, -1.84) | -2.03 (-2.38, -1.67) |  | |
CMDs | Low | 15,433 | 2.58 (2.37–2.82) | 2.30 (2.10– 2.52) |  | -2.85 (-3.16, -2.54) | -2.58 (-2.89, -2.26) |  | |